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1

Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus

Flyak, Andrew I., Ilinykh, Philipp A., Murin, Charles D., Garron, Tania, Shen, Xiaoli, Fusco, Marnie L., Hashiguchi, Takao, Bornholdt, Zachary A., Slaughter, James C., Sapparapu, Gopal, Klages, Curtis

Journal:

Year:

2015

Language:

english

File:

PDF, 1.62 MB

english, 2015

2

Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections

Gilchuk, Iuliia, Gilchuk, Pavlo, Sapparapu, Gopal, Lampley, Rebecca, Singh, Vidisha, Kose, Nurgun, Blum, David L., Hughes, Laura J., Satheshkumar, Panayampalli S., Townsend, Michael B., Kondas, Ashley

Journal:

Year:

2016

Language:

english

File:

PDF, 2.10 MB

english, 2016

3

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

Sapparapu, Gopal, Fernandez, Estefania, Kose, Nurgun, Cao, Bin, Fox, Julie M., Bombardi, Robin G., Zhao, Haiyan, Nelson, Christopher A., Bryan, Aubrey L., Barnes, Trevor, Davidson, Edgar, Mysorekar, I

Journal:

Year:

2016

Language:

english

File:

PDF, 8.53 MB

english, 2016

4

Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore

Aiyegbo, Mohammed S., Sapparapu, Gopal, Spiller, Benjamin W., Eli, Ilyas M., Williams, Dewight R., Kim, Robert, Lee, David E., Liu, Tong, Li, Sheng, Woods, Virgil L., Nannemann, David P., Meiler, Jens

Journal:

Year:

2013

Language:

english

File:

PDF, 5.92 MB

english, 2013

5

Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth

Chukwuma, Valentine U., Kose, Nurgun, Sather, D. Noah, Sapparapu, Gopal, Falk, Rachel, King, Hannah, Singh, Vidisha, Lampley, Rebecca, Malherbe, Delphine C., Ditto, Noah T., Sullivan, Jonathan T., Bar

Journal:

Year:

2018

Language:

english

File:

PDF, 2.37 MB

english, 2018

6

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

Kose, Nurgun, Fox, Julie M., Sapparapu, Gopal, Bombardi, Robin, Tennekoon, Rashika N., de Silva, A. Dharshan, Elbashir, Sayda M., Theisen, Matthew A., Humphris-Narayanan, Elisabeth, Ciaramella, Giusep

Journal:

Science Immunology

Year:

2019

Language:

english

File:

PDF, 956 KB

english, 2019

7

Constant Domain-regulated Antibody Catalysis

Sapparapu, G., Planque, S., Mitsuda, Y., McLean, G., Nishiyama, Y., Paul, S.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

8

P2-351: Exceptional catalytic hydrolysis of amyloid-β peptide by immunoglobulin light chain variable domain constructs

Paul, Sudhir, Taguchi, Hiroaki, Planque, Stephanie, Boivin, Stephane, Sapparapu, Gopal, Hara, Mariko, Nishiyama, Yasuhiro

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 79 KB

english, 2008

9

Intracellular neutralization of a virus using a cell-penetrating molecular transporter

Sapparapu, Gopal, Sims, Artez L, Aiyegbo, Mohammed S, Shaikh, Fyza Y, Harth, Eva M, Crowe, James E

Journal:

Year:

2014

Language:

english

File:

PDF, 3.63 MB

english, 2014

10

Exceptional Amyloid Peptide Hydrolyzing Activity of Nonphysiological Immunoglobulin Variable Domain Scaffolds

Taguchi, H., Planque, S., Sapparapu, G., Boivin, S., Hara, M., Nishiyama, Y., Paul, S.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 999 KB

english, 2008

11

Antigen-specific Proteolysis by Hybrid Antibodies Containing Promiscuous Proteolytic Light Chains Paired with an Antigen-binding Heavy Chain

Sapparapu, G., Planque, S. A., Nishiyama, Y., Foung, S. K., Paul, S.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 2.04 MB

english, 2009

12

Deficient synthesis of class-switched, HIV-neutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen

Planque, Stephanie A., Mitsuda, Yukie, Chitsazzadeh, Vida, Gorantla, Santhi, Poluektova, Larisa, Nishiyama, Yasuhiro, Ochsenbauer, Christina, Morris, Mary-Kate, Sapparapu, Gopal, Hanson, Carl V., Mass

Journal:

Year:

2014

Language:

english

File:

PDF, 338 KB

english, 2014

13

Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus

Smith, Scott A., Silva, Laurie A., Fox, Julie M., Flyak, Andrew I., Kose, Nurgun, Sapparapu, Gopal, Khomadiak, Solomiia, Ashbrook, Alison W., Kahle, Kristen M., Fong, Rachel H., Swayne, Sherri, Doranz

Journal:

Cell Host & Microbe

Year:

2015

Language:

english

File:

PDF, 1.80 MB

english, 2015

14

Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites

Winarski, Katie L., Thornburg, Natalie J., Yu, Yingchun, Sapparapu, Gopal, Crowe, James. E., Spiller, Benjamin W.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

15

Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus

Smith, Scott A., Silva, Laurie A., Fox, Julie M., Flyak, Andrew I., Kose, Nurgun, Sapparapu, Gopal, Khomandiak, Solomiia, Ashbrook, Alison W., Kahle, Kristen M., Fong, Rachel H., Swayne, Sherri, Doran

Journal:

Cell Host & Microbe

Year:

2015

Language:

english

File:

PDF, 97 KB

english, 2015

16

Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity

Long, Feng, Fong, Rachel H., Austin, Stephen K., Chen, Zhenguo, Klose, Thomas, Fokine, Andrei, Liu, Yue, Porta, Jason, Sapparapu, Gopal, Akahata, Wataru, Doranz, Benjamin J., Crowe, James E., Diamond,

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 2.31 MB

english, 2015

17

Dengue virus prM-specific human monoclonal antibodies with virus replication enhancing properties recognize a single immunodominant antigenic site

Smith, Scott A., Nivarthi, Usha K., de Alwis, Ruklanthi, Kose, Nurgun, Sapparapu, Gopal, Bombardi, Robin, Kahle, Kristen M., Pfaff, Jennifer M., Lieberman, Sherri, Doranz, Benjamin J., de Silva, Aravi

Journal:

Journal of Virology

Year:

2015

Language:

english

File:

PDF, 903 KB

english, 2015

18

Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization

Willis, Jordan R., Finn, Jessica A., Briney, Bryan, Sapparapu, Gopal, Singh, Vidisha, King, Hannah, LaBranche, Celia C., Montefiori, David C., Meiler, Jens, Crowe, James E.

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.82 MB

english, 2016

19

Determinants of VH1-46 Cross-Reactivity to Pemphigus Vulgaris Autoantigen Desmoglein 3 and Rotavirus Antigen VP6

Cho, M. J., Ellebrecht, C. T., Hammers, C. M., Mukherjee, E. M., Sapparapu, G., Boudreaux, C. E., McDonald, S. M., Crowe, J. E., Payne, A. S.

Journal:

The Journal of Immunology

Year:

2016

Language:

english

File:

PDF, 1.83 MB

english, 2016

20

Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody

Shanker, Sreejesh, Czakó, Rita, Sapparapu, Gopal, Alvarado, Gabriela, Viskovska, Maria, Sankaran, Banumathi, Atmar, Robert L., Crowe, James E., Estes, Mary K., Prasad, B. V. Venkataram

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.75 MB

english, 2016

21

Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to Dengue Virus Serotype 4 Infection and Vaccination

Nivarthi, Usha K., Kose, Nurgun, Sapparapu, Gopal, Widman, Douglas, Gallichotte, Emily, Pfaff, Jennifer M., Doranz, Benjamin J., Weiskopf, Daniela, Sette, Alessandro, Durbin, Anna P., Whitehead, Steve

Journal:

Journal of Virology

Year:

2017

Language:

english

File:

PDF, 2.53 MB

english, 2017

22

A human antibody against Zika virus crosslinks the E protein to prevent infection

Hasan, S. Saif, Miller, Andrew, Sapparapu, Gopal, Fernandez, Estefania, Klose, Thomas, Long, Feng, Fokine, Andrei, Porta, Jason C., Jiang, Wen, Diamond, Michael S., Crowe Jr., James E., Kuhn, Richard

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 1.46 MB

english, 2017

23

Monoclonal Antibodies Against the Staphylococcus aureus Bicomponent Leukotoxin AB Isolated Following Invasive Human Infection Reveal Diverse Binding and Modes of Action

Thomsen, Isaac P., Sapparapu, Gopal, James, David B. A., Cassat, James E., Nagarsheth, Meera, Kose, Nurgun, Putnam, Nicole, Boguslawski, Kristina M., Jones, Lauren S., Wood, James B., Creech, Clarence

Journal:

The Journal of Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 2.05 MB

english, 2017

24

Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus

Fernandez, Estefania, Kose, Nurgun, Edeling, Melissa A., Adhikari, Jagat, Sapparapu, Gopal, Lazarte, Susana M., Nelson, Christopher A., Govero, Jennifer, Gross, Michael L., Fremont, Daved H., Crowe, J

Journal:

Year:

2018

Language:

english

File:

PDF, 4.19 MB

english, 2018

25

A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions

Goo, Leslie, Debbink, Kari, Kose, Nurgun, Sapparapu, Gopal, Doyle, Michael P., Wessel, Alex W., Richner, Justin M., Burgomaster, Katherine E., Larman, Bridget C., Dowd, Kimberly A., Diamond, Michael S

Journal:

Nature Microbiology

Year:

2018

Language:

english

File:

PDF, 1.60 MB

english, 2018